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KMID : 1144820200260020075
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대한의생명과학회지
2020 Volume.26 No. 2 p.75 ~ p.84
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Anti-obesity Effects of Mulberry Leaf and Yacon Extract in Obese Rats
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Lim Yong
Oh Ji-Hye
Park Un-Kyu
Huh Man-Kyu
Hwang Seock-Yeon
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Abstract
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We evaluated the effect of anti-obesitic activity of MYE (mulberry leaf + Yacon tuber) extracted from Morus alba as muberry leaf and Smallanthus sonchifolia as yacon. 1%, 3%, or 5% of MYE were treated to Sprague-Dawley rats exposed to a high-fat diet. MYE treated rats were suppressed weight during four weeks, and they lost weight significantly after six weeks. Common blood chemistry panels related to liver function revealed significant improvement in the MYE-treated groups. The expression of leptin as indicators for obesity was decreased in perirenal fat. Such results indicate that MYE could be a promising candidate for the improvement of obesity. In addition, MYE effected on deceased glucose metabolism, reducing the activities of glucose-6-phosphate dehydrogenase (G-6-PDH) and glucokinase related to glycogen synthesis. The fatty liver was observed in high-fat diet-treated rats, resulting from increased number of adipose cells and Ito cells. However, this pathologic change was significantly improved by administration of MYE. MYE have significant effects on antioxdative function and glycometabolism against high fat diet. Thereby, it seems that MYE prevent fatty liver by high-fat diet. Thus it is suggested that MYE would be worth being developed as an biofunctional food to prevent undesirable effects caused by obesity.
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KEYWORD
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Glucose-6-phosphate dehydrogenase (G-6-PDH), Leptin, Muberry leaf, Obesity, Yacon
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